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KMID : 0043320080310050569
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Archives of Pharmacal Research
2008 Volume.31 No. 5 p.569 ~ p.572
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New Polyunsaturated Fatty Acid Amides Isolated from the Seeds of Zanthoxylum piperitum
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Jang Kyoung-Hwa
Chang Yong-Ha
Kim Dae-Duk
Oh Ki-Bong
Oh Uh-Taek
Shin Jong-Heon
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Abstract
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Five linear fatty acid amides (1-5) of the sanshool class, including two new compounds, were isolated from Zanthoxylum piperitum seeds. Based on combined spectral analyses, the structures of new compounds 4 and 5 were determined to be 2’,3’-dihydroxy--sanshool and 2’,3’-dihydroxy--sanshool, respectively. These compounds exhibited weak cytotoxicity in the A-549 (human lung cancer) cell line.
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KEYWORD
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Zanthoxylum piperitum, Fatty acid amides, Sanshools, Dihydroxy--sanshool, Dihydroxy--sanshool, Cytotoxicity
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